The great potential and interest is represented in the increasing numbers of studies on OA treatment using stem cells. Encouraging results from pre-clinical and clinical trials have provided initial evidence of safety and efficacy for many age-, inflammation- or degenerative-related diseases, including osteoarthritis (OA). Lead by an improved understanding of the role of stem cells, their use as a disease modification treatment option comes into focus. Often conducted surgical interventions are accompanied by significant risks and complications. Current standard treatments target symptomatic relief rather than the underlying mechanisms and hence prevention. With an aging population its prevalence is even going to increase. Osteoarthritis is a leading cause of pain and disability.
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